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The European Medicines Agency (EMA) is reviewing “the risk of suicidal thoughts and thoughts of self-harm” with several drugs in a family of medicines used for weight loss and type 2 diabetes known as GLP-1 receptor agonists, including Ozempic (semaglutide), Saxenda (liraglutide), and Wegovy (semaglutide). Regulators are investigating about 150 possible cases of self-injury and suicidal thoughts connected to these medicines, EMA said in a statement issued July 11.
In the UK, the medicines and healthcare products regulatory agency MHRA has launched a similar investigation, according to a July 26 report by Reuters. British regulators are looking at drugs involved in the EMA investigation, as well as the GLP-1 drugs Bydureon (exenatide), Lyxumia (lixisenatide), and Trulicity (dulaglutide), Reuters reported.
“I think it is appropriate that there is additional oversight to the use of these medications, especially as they expand into broader public use and misuse,” says Beverly Tchang, MD, an assistant professor of clinical medicine at Cornell University in Ithaca, New York, who treats patients with obesity and type 2 diabetes at at Weill Cornell Medicine in New York City.
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